Bridge Organics chemists have considerable experience in the preparation and analysis (NMR, mass spec) of 2
H and 13
C compounds. The process involves designing a synthetic route amenable to incorporation of the label(s), carrying out the preparation “cold”, and once well worked out, running the chemistry with the appropriate labeled compounds. Bridge Organics chemists could readily apply this expertise to other stable isotopes.
Stable labels such as deuterium have been incorporated into target molecules by several different methods at Bridge. These include catalytic hydrogenations with D2
O, chemical reductions with LiAlD4
; for example, and replacement of exchangeable hydrogens using D2
O. Likewise, 13
C labeling can be carried out by a variety of methods well known to Bridge chemists.